Walter Cannon set out the first law of autonomic denervation in the 1940's. He found that denervation of a motor unit resulted in supersensitivity in the zone of innervation. The second law of autonomic denervation states that if autonomic nerves are injured then this may have effects on the central nervous system. Formal studies use the term "central sensitisation"..
It is clear that injuries to pelvic autonomic nerves result in:
(1) changes in form - particularly hypoplasia (or hyperplasia in a "generative" organ" e.g. leiomyoma or adenomyosis)
(2) changes in function - including visceral dysmotility as in the uterus and Fallopian tube
(3) susceptibility to infection - denervated epithelia are more susceptible to infection and those infections skew towards opportunistic organisms
(4) susceptibility to toxins - autonomic "irritants" include stress, alcohol, tobacco, drugs, infections, etc (Bannister R, "Autonomic Failure, 2nd Edition)
(5) aberrant reinnervation - which takes several forms and results in hyperalgesiae or allodyniae cf gynaecological symptoms where "light touch causes pain/discomfort"
(6) CNS changes - any changes to peripheral nerves register changes in the central nervous system with varied clinical effects
Developing Dr Cannons' studies there may be as many as six "laws" of autonomic denervation that account for some forms of many chronic diseases through diverse and cumulative mechanisms.
Deep infiltrating endometriosis
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There was an interesting study from a French group in the on-line version
of Fertility and Sterility this week. The researchers compared the
clinical reco...
This is useful guidance. The effects of autonomic denervation, local anesthesia, and electrical stimulation of the pancreatic intraductal pressure were studied in a group of dogs. The results of that study suggest that the autonomic nervous system can affect the pancreatic duct pressure, through its action on the sphincter mechanism of the main papilla, and in the ductal system.
ReplyDeleteThese information are amazing and very down-to-earth. Much of it seemed like common sense, but, it was brilliant to hear it from someone who has been through it all. Thanks for taking the time to share this great advice with the world!
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